Detalhe da pesquisa
1.
Oncogenic Signaling Pathways in The Cancer Genome Atlas.
Cell
; 173(2): 321-337.e10, 2018 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29625050
2.
RAS Proteins and Their Regulators in Human Disease.
Cell
; 170(1): 17-33, 2017 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28666118
3.
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
Cell
; 163(5): 1237-1251, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26590425
4.
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
Mol Cell
; 82(13): 2443-2457.e7, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35613620
5.
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Nature
; 609(7926): 408-415, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35831509
6.
SPRED proteins and their roles in signal transduction, development, and malignancy.
Genes Dev
; 34(21-22): 1410-1421, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872193
7.
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
Proc Natl Acad Sci U S A
; 120(5): e2208960120, 2023 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36689660
8.
Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR.
J Biol Chem
; 300(2): 105650, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38237681
9.
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors.
Proc Natl Acad Sci U S A
; 119(5)2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35091470
10.
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
Proc Natl Acad Sci U S A
; 119(1)2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34983849
11.
The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
J Biol Chem
; 299(6): 104789, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37149146
12.
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.
Anal Chem
; 96(13): 5223-5231, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38498381
13.
UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.
Proc Natl Acad Sci U S A
; 118(31)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330832
14.
RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proc Natl Acad Sci U S A
; 118(33)2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34380736
15.
Long-term ecological research in freshwaters enabled by regional biodiversity collections, stable isotope analysis, and environmental informatics.
Bioscience
; 73(7): 479-493, 2023 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37841229
16.
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.
Nature
; 551(7679): 247-250, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29088702
17.
Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders.
Proc Natl Acad Sci U S A
; 117(22): 12121-12130, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32424096
18.
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Proc Natl Acad Sci U S A
; 117(39): 24258-24268, 2020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32913056
19.
DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs.
J Biol Chem
; 296: 100023, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33410398
20.
Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics.
J Am Chem Soc
; 144(9): 4196-4205, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35213144